Timothy Hinks

Timothy Hinks

Todd-Bird Non-Stipendiary JRF in Clinical Medicine
Clinical Medicine
MA Cantab, MB MCh, MRCP, PhD

Timothy Hinks studied medicine at Pembroke College, Cambridge and Wadham College, Oxford, before undertaking junior medical training in Oxford. He then combined a period of research into the application of novel immunodiagnostics in tuberculosis, with work for the Christian Medical Fellowship in southern England, Russia and Albania. He completed his higher specialist training respiratory and general medicine in the Southampton region, where he undertook a PhD in the role of T cells in the immunology of asthma, with a subsequent postdoctoral research fellowship in Melbourne, Australia. He now leads a research group in the Nuffield Department of Medicine alongside caring for patients in the Oxfordshire Severe Asthma Service.

Teaching

Dr Hinks provides bedside teaching, tutorials in clinical medicine and educational supervision for New College medical students during their 4th to 6th years.

Research Interests

The goal of the Hinks group is to better understand the immune responses which protect us from lung infections or can drive airways inflammation, to help develop new treatments to prevent exacerbations of lung diseases and to accelerate the development of improved vaccines. Thanks to two recent major funding awards from the Wellcome Trust we have a specific focus on the of the bacterium Haemophilus influenzae and related organisms in chronic mucosal infections and in non-eosinophilic airways inflammation in severe asthma and the immune mechanisms underlying macrolide efficacy in asthma.

Selected Publications

  • Hilvering B, Hinks TSC et al. (2018) Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma. Mucosal Immunology. 2018 Jun 15.
  • Wang H, et al. (2018) MAIT cells protect against pulmonary Legionella longbeachae infection. Nature Communications. 9, (1) 3350  
  • Singhania A et al. Multi-tissue transcriptomics delineates the diversity of airway T cell functions in asthma. American Journal of Respiratory Cell and Molecular Biology. 2018 58 (2) 261-270
  • Hinks TS et al. Steroid-induced deficiency of mucosal-associated invariant T cells in the COPD lung: implications for NTHi infection. American Journal of Respiratory and Critical Care Medicine 2016 194 (10) 1208-1218
  • Hinks TS MAIT cells in autoimmunity, immune mediated diseases and airways disease. Immunology 2016 148 (1) 1-12.
  • Hinks TS et al. Multidimensional endotyping in severe asthma reveals inflammatory heterogeneity in MMPs and YKL-40 Journal of Allergy and Clinical Immunology 2016 138 (1) 61-75. 
  • Hinks TS et al. Innate and adaptive T cells in asthma: relationship to severity and therapy Journal of Allergy and Clinical Immunology. 2015 136 (2) 323-33

Links

https://www.expmedndm.ox.ac.uk/principal-investigators-2/researcher/timothy-hinks

@HinksLab

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