Dr. Regan-Komito received his Bachelors degree in Biochemistry and Cell Biology (B.A. Mod, 1st class honours) from Trinity College Dublin in 2011. He then moved to the Sir William Dunn School of Pathology (University of Oxford) to pursue his D.Phil in the field of immunology and chronic inflammatory disease, specifically investigating novel anti-inflammatory and pro-resolution mediators in the context of atherosclerosis. During this time Dr. Regan-Komito worked in the laboratory of Professor David R. Greaves and was funded by a 4 year PhD studentship awarded by the British Heart Foundation (2011-2015). He was also actively involved in undergraduate teaching of medical students, including practical classes, small group seminars as well as direct supervision of FHS laboratory projects.
Following his D.Phil, Dr. Regan-Komito joined the Kennedy Institute of Rheumatology (University of Oxford) as a Postdoctoral Research Fellow working with Dr. Thibault Griseri and Professor Fiona Powrie (2016-present).
Dr. Regan-Komito conducts tutorials in pathology for College Medical students. He also contributes to graduate student training and supervision at the Kennedy Institute of Rheumatology.
Dr. Regan-Komito’s research interests align with the fields of autoimmune and chronic inflammatory disease. His research currently focuses on the mechanisms by which dysregulation of haematopoietic stem cells and myeloid cell progenitors drive disease during inflammatory arthritis. In addition, he is investigating the role played by the microbiota in the regulation of myelopoiesis during arthritis. He employs a range of pre-clinical in vivo and ex vivo disease models and methodologies to interrogate novel disease mechanisms that drive the inflammatory disease, ankylosing spondylitis. Further details of Dr. Regan-Komito’s research can be found here: https://www.kennedy.ox.ac.uk/team/daniel-regan-komito
- Daniel Regan-Komito, Sophia Valaris, Theodore S. Kapellos Lewis Taylor, David R. Greaves and Asif J. Iqbal. (2017). Absence of the non-signalling chemerin receptor CCRL2 exacerbates acute inflammatory responses in vivo. Frontiers in Immunology. (Accepted for publication).
- Simao Laranjeira, Daniel Regan-Komito, Asif J Iqbal, David R Greaves, Stephen J Payne, Piotr Orlowski. (2017). A model for the optimization of anti-inflammatory treatment with Chemerin. Interface Focus. (Accepted for publication).
- Jyoti Patel, Eileen McNeill, Gillian Douglas, Ashley B. Hale, Joseph de Bono, Regent Lee, Asif J. Iqbal, Daniel Regan-Komito, Elena Stylianou, David R. Greaves, Keith M. Channon. (2015). Regulator of G-protein Signaling-1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signaling. Nature Communications.
- McNeill E, Iqbal AJ, Patel J, White GE, Regan-Komito D, Greaves DR, Channon KM. (2014).Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.
- Iqbal AJ, McNeill E, Kapellos TS, Regan-Komito D, Norman S, Burd S, Smart N, Machemer DE, Stylianou E, McShane H, Channon KM, Chawla A, Greaves DR. (2014) Human CD68 promoter directs GFP transgene expression in mouse myeloid cells, allowing analysis of monocyte to macrophage differentiation in vivo.
- Iqbal AJ, Regan-Komito D, Christou I, White GE, McNeill E, Kenyon A, Taylor L, Kapellos TS, Fisher EA, Channon KM, Greaves DR (2013).A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages. PLoS One. 2013;8(3):e58744